Omega-3 fatty acids have antithrombotic activity and should be given with caution to patients with hemorrhagic disorders or to those receiving anticoagulants or other drugs affecting coagulation. Hepatic function should be monitored in patients with hepatic impairment, particularly if receiving high doses. Caution may also be required in asthmatic patients sensitive to aspirin since omega-3 fatty acids may affect prostaglandin synthesis.